英文名稱    ERMAP   

中文名稱    紅細胞膜相關(guān)蛋白ERMAP抗體   

別    名    ERMAP; ERMAP_HUMAN; Erythroblast membrane associated protein; Erythroid membrane associated protein; Erythroid membrane-associated protein; hERMAP; MGC118810; MGC118811; MGC118812; MGC118813; PRO2801; Radin blood group (Rd); Radin blood group antigen; RD; SC; Scianna blood group (Sc); Scianna blood group antigen.   

供 應(yīng) 商    遠慕生物  

研究領(lǐng)域    細胞生物  發(fā)育生物學(xué)  信號轉(zhuǎn)導(dǎo)  干細胞  細胞膜蛋白     

抗體來源    Rabbit   

克隆類型    Polyclonal   

交叉反應(yīng)    Human, Mouse, Rat,    

產(chǎn)品應(yīng)用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 紅細胞膜相關(guān)蛋白ERMAP抗體（石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.   

分 子 量    50kDa   

細胞定位    細胞漿 細胞膜    

性    狀    Lyophilized or Liquid   

濃    度    1mg/1ml   

免 疫 原    KLH conjugated synthetic peptide derived from human ERMAP   

亞    型    IgG   

純化方法    affinity purified by Protein A   

儲 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4   

保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.   

紅細胞膜相關(guān)蛋白ERMAP抗體產(chǎn)品介紹    background:

ERMAP is a single-pass type one membrane protein that belongs to the immunoglobulin superfamily. Expressed in cord blood, fetal liver and adult bone marrow, ERMAP is thought to function as a cell adhesion molecule in erythroid cells and is responsible for expression of the Scianna/Radin (Sc/Rd) blood group antigen system. The Sc/Rd system is comprised of seven antigens that are present on the surface of red blood cells and have a variety of functions ranging from protein transport to cell adhesion. These seven blood antigens can differ in their expression within a population and may sometimes differ between mother and child. A fetus expressing different blood antigens than its mother may cause the mother to produce antibodies against the fetal blood. This condition is known as hemolytic disease of the newborn (HDN) and is characterized by jaundice, anemia and in some cases, infant death.

Function:
Possible role as a cell-adhesion or receptor molecule of erythroid cells.

Subcellular Location:
Cell membrane. Cytoplasm.

Tissue Specificity:
Expressed in erythroid-enriched bone marrow (at protein level). Highly expressed in bone marrow and to a lower extent in leukocytes, thymus, lymph node and spleen.

Post-translational modifications:
Glycosylated.

Similarity:
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 B30.2/SPRY domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Database links:
UniProtKB/Swiss-Prot: Q96PL5.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.